H3K4me3 Polyclonal Antibody/H3K4me3多克隆抗体

货号：PA5-27029

规格：50 µg

价格：5611

产品类型：抗体和染料

品牌：Thermo Fisher

抗原：Synthetic trimethylated peptide surrounding Lysine

物种：其它

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	多抗	同型对照：
浓度：	0.7 mg/mL	用法：	1:500(ICC)；1:500(IF)；1:1000(Array)

产品详细信息This antibody is predicted to react with many species including rat, chicken, xenopus, drosophila, and plant based on 100% sequence homology.靶标信息Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail ofhistone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.

数据：

H3K4me3 Antibody (PA5-27029) in ICCImmunocytochemical analysis of Histone H3.2 K4me3 in HeLa cells with FITC (green), usingProduct # PA5-27029at a dilution of 1:200. Nuclei were counterstained with DAPI (blue). H3K4me3 Antibody (PA5-27029) in ARRAYDot Blot analysis of H3K4me3 using the peptides listed above in 10, 3, and 1 picomoles of peptide.

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参考文献：

1. Stem cells (Dayton, Ohio)Novel cell lines isolated from mouse embryonic stem cells exhibiting de novo methylation of the E-cadherin promoter.

技术参数

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