RNF20 Polyclonal Antibody
货号：PA5-19597
规格：100 µg
价格：4880
产品类型：标签抗体
品牌：Thermo Fisher
抗原：Synthetic peptide conjugated to KLH derived from w
物种：其它
宿主：兔
抗体亚型：IgG1, kappa
荧光染料：Alexa Fluor 488
| 类型: | 一抗 | 同型对照： | |
| 浓度： | 0.2 mg/mL | 用法： | 1 µg/mL(ICC);1 µg/mL(IF)；1:50 (IHC(P));1 µg/mL(WB) |
产品详细信息Heat mediated antigen retrieval recommended prior to tissue staining.This antibody is predicted to react with mouse based on sequence homology. 靶标信息RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. RNF20 selectively suppresses the expression of some genes such as several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). In contrast, RNF20 also positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. Together with the deubiquitinase USP44, RNF20 regulates stem cell differentiation by modulating H2B monoubiquitination.
| 数据： |
| RNF20 Antibody (PA5-19597) in WB Western blot analysis of HeLa Whole Cell Lysate using Product # PA5-19597, RNF20 primary antibody at a dilution of 1 µg/mL (lane 1). Staining of Jurkat Whole Cell Lysate at a dilution of 1 µg/mL (lane 2). Blot treated with a secondary HRP-conjugated Goat polyclonal anti-Rabbit antibody was used at a dilution of 1:3000. |
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