Human Podoplanin ELISA Kit/人Podoplanin ELISA试剂盒
货号：EH375RB,EH375RBX5,EH375RBX10
规格：96 tests,5X96 tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 0.16 ng/mL |
| 检测范围 | 0.16-40 ng/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | Podoplanin |
| Protein aliases | 29kDa cytosolic podoplanin intracellular domain, Aggrus, Glycoprotein 36, glycoprotein, 36-KD, Gp36, hT1alpha-1, hT1alpha-2, lung type I cell membrane associated glycoprotein, lung type-I cell membrane-associated glycoprotein (T1A-2), PA2.26 antigen, PDPN, PICD, Podoplanin, T1-alpha, T1A |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | AGGRUS, GP36, Gp38, GP40, HT1A-1, OTS8, PA2.26, PDPN, PSEC0003, PSEC0025, T1A, T1A-2, T1A2, TI1A |
| Gene ID | (Human) 10630 |
| Gene symbol | PDPN |
| UniProt ID | (Human) Q86YL7 |
| Human Podoplanin quantitates human Podoplanin in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Podoplanin.人Podoplanin可定量检测血清，血浆，上清液中的人Podoplanin。 该检测试剂盒将专门识别天然和重组人Podoplanin。Target information 靶标信息Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.Podoplanin（PDPN，T1A，gp38，Aggrus）是一种粘蛋白1型糖蛋白，分子量为40-43 kDa。 Podoplanin在许多肿瘤和正常细胞中表达，尤其是在淋巴上皮细胞和滤泡DC中。 Podoplanin定位在外周淋巴组织的基质细胞和胸腺上皮细胞中。作为淋巴管的调节剂，podoplanin可能在维持足细胞独特形状方面发挥作用。 Podoplanin似乎是CLEC-2的配体，其表达与表达更大浸润和转移潜能的肿瘤正相关。 Podoplanin直接参与细胞迁移，帮助转移形成和肿瘤细胞入侵组织。此外，还已经确定通过Cas的Src激活来诱导podoplanin表达，并且最近，在Th17细胞上存在podoplanin存在的迹象。下面的初步研究表明在人类PBMC的CD4 +细胞中，有一个小而独特的群体存在Podoplanin。 Podoplanin蛋白的功能障碍与淋巴管瘤和声门下肿瘤等疾病有关。由于蛋白质的生理功能，Podoplanin也被提议作为肺损伤的标志物。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。 |
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