KMT2D Polyclonal Antibody
货号：PA5-57490
规格：100 µL
价格：5548
产品类型：标签抗体
品牌：Thermo Fisher
抗原：Recombinant protein corresponding to Human KMT2D
物种：人
宿主：兔
抗体亚型：IgG
荧光染料：其它
| 类型: | 一抗 | 同型对照： | |
| 浓度： | 0.3 mg/mL | 用法： | 0.25-2 µg/mL(ICC);0.25-2 µg/mL(IF)；1:200-1:500(IHC) |
产品详细信息Immunogen sequence: AQLADTLFSK GLGPWDPPDN LAETQKPEQS SLVPGHLDQV NGQVVPEASQ LSIKQEPREE PCALGAQSVK REANGEPIGA PGTSNHLLLA GPRSEAGHLL LQKLLRAKNV QLSTGRGSEG LRAEINGHIHighest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 84%. 靶标信息KMT2D is a histone methyltransferase that methylates Lys-4 of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. KMT2D acts as a coactivator for estrogen receptors by being recruited by ESR1 and activating transcription. KMT2D is involved in chromatin organization, chormatin silencig, oocyte growth, oogenesis, and a positive regulation of cell proliferation. Mutations in the KMT2D gene cause Kabuki syndrome (KABUK1) which results in congential mental retardation syndrome.
| 数据： |
| KMT2D Antibody (PA5-57490) in IF Immunofluorescent staining of KMT2D in human cell line A-431 shows positivity in nucleus, plasma membrane and cytoplasm. Samples were probed using a KMT2D Polyclonal Antibody (Product # PA5-57490).KMT2D Antibody (PA5-57490) in IHC Immunohistochemical staining of KMT2D in human cervix, uterine using KMT2D Polyclonal Antibody (Product # PA5-57490) shows weak nuclear positivity in squamous epithelial cells. |
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QQ:1749072012