Human SIGIRR ELISA Kit/人SIGIRR ELISA试剂盒
货号：EH422RB,EH422RBX5,EH422RBX10
规格：96 tests,5X96 tests,10X96 tests
价格：6641,29887,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 2 ng/mL |
| 检测范围 | 2-500 ng/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | SIGIRR |
| Protein aliases | Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, single immunoglobulin domain IL1R1 related, Single immunoglobulin domain-containing IL1R-related protein, TIR8, Toll/interleukin-1 receptor 8 |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | IL-1R8, SIGIRR, TIR8, UNQ301/PRO342 |
| Gene ID | (Human) 59307 |
| Gene symbol | SIGIRR |
| UniProt ID | (Human) Q6IA17 |
| Human SIGIRR quantitates human SIGIRR in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human SIGIRR.人SIGIRR定量测定血清，血浆，上清液中的人SIGIRR。 该检测试剂盒将只识别天然和重组人SIGIRR。Target information 靶标信息SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFkappaB unlike similar fusion proteins of other IL-1R related molecules. Phylogenetic data that suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.SIGIRR（单个Ig IL-1R相关分子）是白介素1受体（IL-1R）超家族的新成员。 尽管显示了IL-1R和Toll超家族的典型保守基序，但在结构和功能上均与之不同。 SIGIRR在其细胞外部分仅具有一个Ig结构域，而IL-1R家族包含3个Ig折叠。 一个异常长的胞质结构域使人联想起果蝇Toll的结构，但SIGIRR肽序列与IL-1RI更紧密相关。 嵌合体，其中SIGIRR细胞内结构域与IL-1R细胞外结构域融合，不激活NFkappaB，这与其他IL-1R相关分子的相似融合蛋白不同。 系统发育数据表明，质膜蛋白SIGIRR是MyD88在哺乳动物中的近亲。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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