PCAF Polyclonal Antibody

货号：PA5-22046

规格：100 µL

价格：4880

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Synthetic peptide corresponding to a region within

物种：人/小鼠

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	1 mg/mL	用法：	1:500-1:3000(WB)

产品详细信息Recommended positive controls: 293T, A431, A375, HeLa, HeLa nuclear extract, MFB.Predicted reactivity: Mouse (100%).Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. 靶标信息PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. PCAF also acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. It is involved in heart and limb development by mediating acetylation of TBX5 and acetylation regulating nucleocytoplasmic shutting of TBX5.

数据：

PCAF Antibody (PA5-22046) in WBWestern Blot analysis of PCAF was performed by separating 30 µg of various whole cell lysates by 7.5 % SDS-PAGE. Proteins were transferred to a membrane and probed with a PCAF Polyclonal Antibody (Product # PA5-22046) at a dilution of 1:1000. A. 293T, B. A431, C. A375. PCAF Antibody (PA5-22046) in WB Western Blot analysis of PCAF was performed by separating 30 µg of HeLa whole cell and nuclear extracts by 7.5% SDS-PAGE. Proteins were transferred to a membrane and probed with a PCAF Polyclonal Antibody (Product # PA5-22046) at a dilution of 1:1000.

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