Mer (MERTK) Human ELISA Kit/人Mer（MERTK）ELISA试剂盒
货号：BMS2285,BMS2285TEN
规格：96 Tests,10X96 Tests
价格：6943,44895
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 6.96 pg/mL |
| 检测范围 | 11.72-750 pg/mL |
样本类型/体积 | 血清 5 μL 血浆 5 μL 细胞裂解液 5 μL |
操作时间 | 1 hr 20 min |
测试时间 | 3 hr 30 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | 7.4% |
| 批内变异系数（CV） | 3.9% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 底物溶液 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | MERTK |
| Protein aliases | c-mer proto-oncogene tyrosine kinase, MER receptor tyrosine kinase, MERTK, MER, RP38, c-mer, Tyro12, c-Eyk, MER proto-oncogene, tyrosine kinase, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, STK kinase, Tyrosine-protein kinase Mer |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | c-Eyk, c-mer, MER, MERTK, RP38, Tyro12 |
| Gene ID | (Human) 10461 |
| Gene symbol | MERTK |
| UniProt ID | (Human) Q12866 |
| The Human Mer ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative detection of human Mer.人Mer ELISA试剂盒是用于定量检测人Mer的酶联免疫吸附法。Target information 靶标信息Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.受体酪氨酸激酶，通过与包括LGALS3，TUB，TULP1或GAS6在内的几种配体结合，将信号从细胞外基质传导至细胞质。调节许多生理过程，包括细胞存活，迁移，分化和凋亡细胞的吞噬作用（胞吞作用）。细胞表面上的配体结合诱导MERTK在其细胞内结构域上的自磷酸化，从而为下游信号分子提供对接位点。通过配体激活后，与GRB2或PLCG2相互作用并诱导MAPK1，MAPK2，FAK / PTK2或RAC1磷酸化。 MERTK信号传导在各种过程中发挥作用，例如凋亡细胞的巨噬细胞清除，血小板聚集，细胞骨架重组和吞噬。在视网膜色素上皮（RPE）中的功能是调节杆外节段片段吞噬作用。在通过激活STAT1抑制Toll样受体（TLRs）介导的先天免疫反应中也起着重要作用，STAT1选择性地诱导细胞因子信号转导SOCS1和SOCS3抑制剂的产生。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售 |
| 数据： |
| Mer (MERTK) Human ELISA KitRepresentative standard curve for Human Mer. |
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