| Porcine IL-17F quantitates porcine IL-17F in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant porcine IL-17F.猪IL-17F可定量测定血清，血浆，上清液中的猪IL-17F。该检测试剂盒将只识别天然和重组猪IL-17F。Target information 靶标信息IL-17F (Interleukin 17F, CTLA-8)) is a cytokine belonging to the IL-17 family that is produced by inflammatory cells such as activated T cells, mast cells, and basophils. IL-17F is involved in allergic airway inflammation, and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. IL-17F may be secreted as a homodimer, or a heterodimer with IL17A. It acts by binding to the type I receptor, IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflammation by increasing chemokine production. IL-17F also stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-beta (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17F is produced, and exists, as a homo-dimer, with homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterized and highly expressed by activated effector memory T cells. IL-17F has been found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.IL-17F（白介素17F，CTLA-8）是属于IL-17家族的一种细胞因子，是由诸如活化T细胞，肥大细胞和嗜碱性粒细胞之类的炎性细胞产生的。 IL-17F与过敏性气道炎症有关，可在支气管上皮细胞，静脉内皮细胞，成纤维细胞和嗜酸性粒细胞中诱导多种细胞因子，趋化因子和粘附分子。 IL-17F可能被分泌为IL17A的同二聚体或异二聚体。它通过与I型受体IL-17R结合而起作用，通过增加趋化因子的产生来帮助在炎症部位募集单核细胞和中性粒细胞。 IL-17F还刺激其他促炎性细胞因子TNFα，IL-1 beta，IL-6和IL-8的诱导，并且有报告强烈表明IL-17参与了几种慢性炎症性疾病，如类风湿性关节炎，牛皮癣和多发性硬化症。 TGF-beta（分化）和IL-23（扩增）是诱导和维持Th17（产生IL-17的细胞）所必需的，而Th17细胞又可以诱导其他促炎性细胞因子。 IL-17F产生并作为与疱疹病毒早期蛋白具有同源性的同型二聚体存在，是该细胞因子家族的六种成员之一（IL-17A-F），并且被很好地表征和表达激活的效应记忆T细胞。已经发现IL-17F抑制内皮细胞的血管生成并诱导内皮细胞产生IL2，TGFB1 / TGFB和单核细胞趋化蛋白-1。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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