HDAC3 Polyclonal Antibody

货号：PA5-88613

规格：100 µL

价格：4732

产品类型：标签抗体

品牌：Thermo Fisher

抗原：A synthetic peptide corresponding to a sequence wi

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	1.16 mg/mL	用法：	1:50-1:200(ICC);1:50-1:200(IF);1:50-1:200(IHC(P));1:500-1:2000(WB)

产品详细信息Positive Samples: Mouse brain; Cellular Location: Cytoplasm, Nucleus, cytosol靶标信息Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

数据：

HDAC3 Antibody (PA5-88613) in ICCImmunocytochemistry-Immunofluorescence analysis of HDAC3 was performed in HeLa cells using HDAC3 Polyclonal Antibody (Product # PA5-88613) at a dilution of 1:100. Blue: DAPI for nuclear staining. HDAC3 Antibody (PA5-88613) in IHCImmunohistochemistry analysis of HDAC3 in paraffin-embedded human colon carcinoma using HDAC3 Polyclonal Antibody (Product # PA5-88613) at a dilution of 1:200. HDAC3 Antibody (PA5-88613) in WBWestern Blot analysis of HDAC3 in extracts of various cell lines using HDAC3 Polyclonal Antibody (Product # PA5-88613) at a dilution of 1:1000. A HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.

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