ING4 Polyclonal Antibody
货号：40-7700
规格：100 µg
价格：4532
产品类型：标签抗体
品牌：Thermo Fisher
抗原：Synthetic peptide derived from the internal region
物种：人/小鼠
宿主：兔
抗体亚型：IgG
荧光染料：Alexa Fluor 488
| 类型: | 一抗 | 同型对照： | |
| 浓度： | 0.25mg/mL | 用法： | |
靶标信息The ING4 gene belongs to the ING (Inhibitor of Growth) family of tumor suppressors. All five members of the ING protein family identified to date contain a highly conserved plant homeodomain (PHD) finger motif at the C-terminal end, which is found in transcription factors that modulate chromatin structure. ING proteins have been shown to form transcriptional complexes leading to activation of responsive genes that mediate a wide range of cellular functions, including growth arrest, DNA repair, gene transcription, apoptosis, and senescence. The candidate tumor suppressor ING4 has a role in brain tumor pathogenesis, and is involved in regulating tumor growth and angiogenesis. Expression of ING4 is reduced in gliomas compared to normal brain tissue, and ING4 reduction correlates with progression from lower to higher grades of tumors. ING4 physically interacts with the p65 (RelA) subunit of NF-kB and represses transcription of NF-kB responsive genes. Inactivating mutations in ING4 transcripts have been described in various human cancer cell lines, and deletion of the ING4 locus has been detected in 10-20% of human breast cancer cell lines and tumors.
| 数据： |
ING4 Antibody (40-7700)Oncology letters 2018 -Figure 1. Expression of ING4 in various CRC cell lines. (A) The mRNA levels of ING4 in various CRC cell lines, and in the normal colonic epithelial cell line CCD841CoN, were detected using reverse transcription-quantitative polymerase chain reaction and then normalized against beta-actin . (B) The protein level of ING4 in various CRC cell lines and the normal colonic epithelial cell line CCD841CoN was detected using western blotting. *P<0.05 vs. all other CRC cell lines. beta-actin was used as the internal control. CRC, colorectal cancer; miR, micro RNA; ING4, inhibitor of growth protein 4. |
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