Mouse beta-NGF ELISA Kit/小鼠beta-NGF ELISA试剂盒
货号：EM9RB,EM9RBX5,EM9RBX10
规格：96 Tests,5X96 Tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：小鼠
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 40 pg/mL |
| 检测范围 | 40-10,000 pg/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | NGF |
| Protein aliases | Beta-nerve growth factor, Beta-NGF, nerve growth factor, beta |
物种（Tested） | 小鼠 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | Ngf, Ngfb |
| Gene ID | (Mouse) 18049 |
| Gene symbol | Ngf |
| UniProt ID | (Mouse) P01139 |
| Mouse beta-NGF quantitates mouse beta-NGF in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse beta-NGF.小鼠β-NGF定量检测血清，血浆，上清液中的小鼠β-NGF。该检测试剂盒将专门识别天然和重组小鼠β-NGF。Target information 靶标信息Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons. Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.神经生长因子（NGF）影响各种神经元和非神经元细胞的存活和分化。该多肽的作用是由于与特异性细胞表面受体结合而产生的，这些受体以高和低亲和力位点的形式存在。尽管两种受体都结合NGF，但只有高亲和力形式才能进行信号转导。用125 I-NGF进行的交联研究表明，大鼠PC12细胞的高亲和力受体与NGF形成Mr 158,000复合物，而低亲和力受体形成Mr 100,000复合物。人和大鼠NGF受体基因的全长cDNA克隆已产生并测序，揭示了这两个物种之间的同源性超过90％。 NGF表现出神经生长刺激活性，并参与调节交感神经和某些感觉神经元的生长和分化。此外，NGF刺激交感和胚胎感觉神经元的分裂和分化。 NGF基因的突变与遗传性感觉和自主神经病5型（HSAN5）有关，而NGF基因表达失调与变应性鼻炎有关。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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