CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), Functional Grade, eBioscience™/CD41a单克隆(eBioMWReg30 (MWReg30)), 功能抗体, eBioscience™

货号： 16-0411-85,16-0411-38, 16-0411-025, 16-0411-050

规格：500 µg,5 mg,25 mg,50 mg

价格：3274,24089,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：CD41a

物种：小鼠

宿主：大鼠

抗体亚型：IgG1, kappa

克隆号：eBioMWReg30 (MWReg30)

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	Rat IgG1 kappa Isotype Control (eBRG1), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	0.25 µg/test（Flow）;Assay-Dependent（功能检测）

产品详细信息Description: The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and adult. CD41 associates with CD61 (gpIIIa, integrin beta III) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin.Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.Applications Reported: This eBioMWReg30 (MWReg30) antibody has been reported for use in flow cytometric analysis and functional assays.Applications Tested: This eBioMWReg30 (MWReg30) antibody has been tested by flow cytometric analysis mouses platelets. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is also involved in blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder.仅用于科研。不用于诊断过程。

数据

CD41a Antibody (16-0411-85)The Journal of clinical investigation 2019 -Published figure using CD41a monoclonal antibody (Product # 16-0411-85)

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参考文献：

流式1.The Journal of clinical investigationSingle-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer."Published figure using CD41a monoclonal antibody (Product # 16-0411-85) in Flow Cytometry"2.eLifeSingle-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis."Published figure using CD41a monoclonal antibody (Product # 16-0411-85) in Flow Cytometry"3.EBioMedicineMediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation."Published figure using CD41a monoclonal antibody (Product # 16-0411-85) in Flow Cytometry"功能检测4.BloodAcute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.AuthorsNieswandt B,Echtenacher B,Wachs FP,Schröder J,Gessner JE,Schmidt RE,Grau GE,Männel DNIF5.Nature medicineAdrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche."Published figure using CD41a monoclonal antibody (Product # 16-0411-85) in Immunofluorescence"6.Development (Cambridge, England)Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels."Published figure using CD41a monoclonal antibody (Product # 16-0411-85) in Immunofluorescence"

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