Armenian Hamster IgG Isotype Control (eBio299Arm), Functional Grade, eBioscience™/Armenian Hamster IgG 同型对照 (eBio299Arm), 功能抗体, eBioscience™

货号：16-4888-81,16-4888-85,16-4888-38,16-4888-025,16-4888-050

规格：50 µg,500 µg,5 mg,25 mg,50 mg

价格：822,2325,24089,72266,120443

产品类型：流式抗体

品牌：eBioscience

物种：Armenian hamster仓鼠

宿主：Armenian hamster仓鼠

抗体亚型：IgG

克隆号：eBio299Arm

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：
浓度：	1 mg/mL	用法：	Assay-Dependent（Flow）;Assay-Dependent（对照）;Assay-Dependent（功能检测）

产品详细信息Description: The eBio299Arm monoclonal antibody is useful as an isotype control immunoglobulin.Applications Reported: The eBio299Arm antibody has been reported for use as an isotype control for flow cytometry.Applications Tested: This eBio299Arm antibody has been tested by LAL assay to determine endotoxin level and by immunofluorescent staining and flow cytometric analysis of mouse splenocytes and normal human peripheral blood.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息The isotype of a primary antibody and the application it is being used in can result in background staining. Primary antibody background noise can be caused by binding to Fc receptors on target cells; by non-specific interactions with cellular proteins, carbohydrates, and lipids; or by cell autofluorescence. Isotype control antibodies can act as negative controls to help differentiate non-specific background signal from specific antibody signal because they have no relevant specificity to a target antigen. While isotype controls are most commonly used in flow cytometry, they are useful in other applications such as chromatin immunoprecipitation (ChIP), immunohistochemistry, and gel shifts. Isotype controls should match with the primary antibody species and isotype so that the level of specific staining by the primary antibody may be accurately determined. If using directly labeled primary antibodies, the isotype control works best if conjugated with the same label as the test antibody.仅用于科研。不用于诊断过程。

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参考文献：

流式1.FEBS lettersOxysterol represses high-affinity IgE receptor-stimulated mast cell activation in Liver X receptor-dependent and -independent manners."16-4888 was used in a Functional assay to link LXR activation to suppression of IL-6 production in BMMCs, but not with reduced FcepsilonRI expression or the degranulation response."AuthorsNunomura S,Endo K,Makishima M,Ra C中和2.PloS oneChlamydial lung infection induces transient IL-9 production which is redundant for host defense against primary infection."16-4888 was used in Blocking experiments to examine the role of IL-9 in eliciting Th cell responses in patients with Chlamydia muridarum lung infection."AuthorsPeng Y,Gao X,Yang J,Shekhar S,Wang S,Fan Y,Yang X功能检测3.Scientific reportsAntibody-dependent fragmentation is a newly identified mechanism of cell killing in vivo."16-4888 was used as a Control in experiments to investigate a novel antibody-dependent cell death pathway."AuthorsLiew PX,Kim JH,Lee WY,Kubes P4.PloS oneThe Receptor CMRF35-Like Molecule-1 (CLM-1) Enhances the Production of LPS-Induced Pro-Inflammatory Mediators during Microglial Activation."16-4888 was used in Functional assays to reveal that CMRF35-like molecule-1 is a co-activating receptor and suggest it plays a key role in the regulation of microglial activation."AuthorsEjarque-Ortiz A,Solà C,Martínez-Barriocanal Á,Schwartz S,Martín M,Peluffo H,Sayós J5.The Journal of biological chemistryPlasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling."16-4888 was used in Immunoprecipitation to suggest that PAI-1-mediated regulation of v3 integrin is critical in controlling TGF signaling and the prevention of fibrotic disease."AuthorsPedroja BS,Kang LE,Imas AO,Carmeliet P,Bernstein AM

技术参数

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