Ly-6G Monoclonal Antibody (1A8-Ly6g), PE
货号：12-9668-80,12-9668-82
规格：25μg,100μg
价格：1029,3035
产品类型：流式抗体
品牌：Thermo Fisher
物种：小鼠
宿主：大鼠
抗体亚型：IgG2a, kappa
克隆号：1A8-Ly6g
荧光染料：PE
| 抗体类型 | 单抗 | 同型对照： | Rat IgG2a kappa Isotype Control (eBR2a), PE |
| 浓度： | 0.2 mg/mL | 用法： | 0.125 μg/test (Flow)； |
| 产品详细信息Description: The monoclonal antibody 1A8-Ly6g reacts with mouse Ly-6G, which is also known as Gr-1. Ly-6G is a 25-kDa GPI protein expressed exclusively by neutrophils. Studies suggest an important role in neutrophil infiltration, recruitment and migration. Ly-6G associates with B2 integrins CD11a and CD11b and can attenuate B2 integrin expression and function. The ligand for Ly-6G is currently unknown.Unlike the RB6-8C5 antibody, 1A8-Ly6g is reported to only bind to Ly-6G found on neutrophils. Moreover, 1A8-Ly6g has been used to deplete neutrophils and reported to have antagonist activity.Applications Reported: This 1A8-Ly6g antibody has been reported for use in flow cytometric analysis.Applications Tested: This 1A8-Ly6g antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息Ly6G (Lymphocyte antigen 6 complex locus G6D) is a component of the myeloid differentiation antigen Gr-1, together with Ly6C. The Ly6G protein has a molecular weight of approximately 21-25 kDa and is expressed by myeloid derived cells in the bone marrow. Ly6G is a good marker for detection of peripheral neutrophils, monocytes and granulocytes. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. The physiological role of Ly6G remains unclear but studies have shown its involvement in anti-tumor response, and studies with neutrophils suggest that Ly6G ligation may have an inhibitory effect on local immune responses |
| 数据 |
| Ly-6G Antibody (12-9668-82) in FlowStaining of C57Bl/6 bone marrow cells with Anti-Mouse Ly-6C PE-Cyanine7 (Product # 25-5932-82) and 0.06 µg of Rat IgG2a K Isotype Control PE (Product # 12-4321-80) (left) or 0.06 µg of Anti-Mouse Ly-6G (Gr-1) PE (right). Total viable cells were used for analysis. |
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