CD4 Monoclonal Antibody (SK3 (SK-3)), PE
货号：12-0047-41,12-0047-42
规格：25 Tests,100 Tests
价格：1112,2629
产品类型：流式抗体
品牌：Thermo Fisher
物种：人
宿主：小鼠
抗体亚型：IgG1, kappa
荧光染料：PE
| 抗体类型 | 单抗 | 同型对照： | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE |
| 浓度： | 5 µL/Test | 用法： | 5 μL (0.125 μg)/test (Flow) |
| 产品详细信息Description: The SK3 monoclonal antibody reacts with human CD4, a 59-kDa cell surface receptor expressed by a majority of thymocytes, a subpopulation of mature T helper cells, and, in low levels, monocytes. CD4 is a receptor for the human immunodeficiency virus (HIV). SK3 blocks HIV binding and mixed lymphocyte reaction. The SK3 and RPA-T4 monoclonal antibodies do not cross-block binding, suggesting recognition of distinct epitopes.Applications Reported: This SK3 (SK-3) antibody has been reported for use in flow cytometric analysis.Applications Tested: This SK3 (SK-3) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017]. |
| 数据 |
| CD4 Antibody (12-0047-41) in FlowStaining of normal human peripheral blood cells with Anti-Human CD3 APC (Product # 17-0038-42) and Mouse IgG1 K Isotype Control PE (Product # 12-4714-81) (left) or Anti-Human CD4 PE (Product # 12-0047-42) (right). Cells in the lymphocyte gate were used for analysis. |
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| 参考文献： |
| 1.The Journal of clinical investigationAlloantigen-specific regulatory T cells generated with a chimeric antigen receptor."Published figure using CD4 monoclonal antibody (Product # 12-0047-42) in Flow Cytometry"2.Scientific reportsCIB1 and CIB2 are HIV-1 helper factors involved in viral entry."Published figure using CD4 monoclonal antibody (Product # 12-0047-42) in Flow Cytometry"3.OncotargetHDAC inhibition potentiates immunotherapy in triple negative breast cancer."Published figure using CD4 monoclonal antibody (Product # 12-0047-42) in Flow Cytometry"4.Scientific reportsCIB1 and CIB2 are HIV-1 helper factors involved in viral entry."Published figure using CD4 monoclonal antibody (Product # 12-0047-42) in Flow Cytometry"5.The Journal of clinical investigationAlloantigen-specific regulatory T cells generated with a chimeric antigen receptor."Published figure using CD4 monoclonal antibody (Product # 12-0047-42) in Flow Cytometry" |
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