| 1.Arthritis research & therapyMast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile."17-5993 was used in Flow cytometry/Cell sorting to suggest that mast cells may play a role in the regulation of the adaptive immune response during the development of arthritis."Authorsvan der Velden D,Lagraauw HM,Wezel A,Launay P,Kuiper J,Huizinga TW,Toes RE,Bot I,Stoop JN2.Cell death and differentiationMitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis."Published figure using IgD monoclonal antibody (Product # 17-5993-82) in Flow Cytometry"3.Journal of immunology (Baltimore, Md. : 1950)CD40 ligand preferentially modulates immune response and enhances protection against influenza virus."17-5993 was used in Flow cytometry/Cell sorting to characterise an increased in vivo load of CD40-targeted Ag upon the secretion of the NP-CD40L fusion protein from adenovirus-infected cells."AuthorsHashem AM,Gravel C,Chen Z,Yi Y,Tocchi M,Jaentschke B,Fan X,Li C,Rosu-Myles M,Pereboev A,He R,Wang J,Li X4. Molecular and cellular biologyLoss of an Igκ gene enhancer in mature B cells results in rapid gene silencing and partial reversible dedifferentiation."17-5993 was used in Flow cytometry/Cell sorting to conclude that Igκ''s downstream enhancers are essential for the establishment and maintenance of transcriptional activity."5. Nature immunologyThe kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling."17-5993 was used in Flow cytometry/Cell sorting to study how immunoglobulin isotype switching is controlled, showing that kinase TBK1 is a pivotal negative regulator of class switching to the immunoglobulin A (IgA) isotype, by attenuating noncanonical signaling via the transcription factor NF-κB."AuthorsJin J,Xiao Y,Chang JH,Yu J,Hu H,Starr R,Brittain GC,Chang M,Cheng X,Sun SC |
QQ:1749072012