Mouse anti Human poly (ADP-ribose) polymerase 1 antibody
货号:VMA00016
规格:100μl
价格:2916
产品类型:免疫组化一抗
品牌:Bio-Rad
抗原:poly (ADP-ribose) polymerase 1
物种:人
宿主:小鼠
抗体亚型:IgG1
克隆号:A6.4.12
荧光染料:Purified
产品介绍 | | |
Mouse anti Human poly (ADP-ribose) polymerase 1 antibodyrecognizes poly (ADP-ribose) polymerase 1 (PARP-1), a nuclear enzyme cleaved during apoptosis (Soldaniet al.2002).PARP-1 is a caretaker enzyme involved in DNA damage repair (Langelieret al.2013). It plays roles in diabetes pathophysiology (Andreoneet al.2012) and tumor proliferation (Rosadoet al2013). As well as protecting cells from genomic instability, PARP-1 is also involved in the development of both inflammatory and immune responses, and cell death by apoptosis and necrosis (Erdélyiet al.2005).PARP-1 represents a promising target for new developments in therapeutic treatment of immune mediated diseases (Rosadoet al.2013) and has considerable potential for delivering selective tumor cell killing while sparing normal cells (Pintonet al.2013).Mouse anti Human poly (ADP-ribose) polymerase 1 antibody recognizes PARP-1 as a single band of ~116 kDa in western blotting in multiple cell line lysates including myeloid, lymphoid, neuronal, adenocarcinoma, sarcoma and embryonic kidney. |
产品详情 | | |
Target Species | Human |
Product Form | Purified IgG - liquid |
Preparation | Mouse monoclonal antibody purified by affinity chromatography on Protein A from tissue culture supernatant. |
Buffer Solution | Phosphate buffered saline |
Preservative Stabilisers | 0.09% Sodium Azide (NaN3) |
Immunogen | Human PARP-1 |
Acknowledgements | PrecisionAb is a trademark of Bio-Rad Laboratories. |
Regulatory | For research purposes only |
Guarantee | 12 months from date of despatch |
存储条件 | | |
Store undiluted at -20°C, avoiding repeated freeze thaw cycles. |
应用 | | |
Application Name | Verified | Min Dilution | Max Dilution |
Western Blotting | √ | | 1/1000 |
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.Flow CytometryUse 10ul of the suggested working dilution to label 106cells or 100ul human whole blood. |
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技术参数 产品应用 wb
产品类型 单克隆抗体
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