mouse anti human HLA ABC:StarBright Blue 700

货号：MCA81SBB700

规格：100 Tests/0.5ml

价格：4055

产品类型：流式抗体

品牌：Bio-Rad

抗原：HLA ABC

物种：人

宿主：小鼠

抗体亚型：IgG2a

克隆号：W6/32

荧光染料：StarBright Blue 700

类型:	单抗	同型对照：	IgG2a
浓度：		用法：	5 µL/test(Flow)
免疫原性：	Purified human tonsil lymphocyte membranes.

Mouse anti Human HLA ABC antibody, clone W6/32recognizes an antigenic determinant shared among products of the HLA A, B and C loci. Clone W6/32 recognizes a conformational epitope, reacting with HLA class I alpha3 and alpha2 domains. The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In humans, this complex is referred to as the human leukocyte antigen (HLA) region. There are 3 major MHC class I proteins encoded by the HLA which are HLA A, HLA B and HLA C. These proteins are found on the surface of almost all nucleated somatic cells.Mouse anti Human HLA ABC antibody, clone W6/32 is routinely tested in flow cytometry on human peripheral blood lymphocytes.

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参考文献：

1. Zuo, J.et al.(2008) The DNase of gammaherpesviruses impairs recognition by virus-specific CD8+ T cells through an additional host shutoff function.J Virol. 82: 2385-93.2. Raftery, M.J.et al.(2002) Hantavirus infection of dendritic cells.J Virol. 76: 10724-33.3. Shi, J.et al.(2008) Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma.Blood. 111: 1309-17.4. Giuliani, F.et al.(2003) Vulnerability of human neurons to T cell-mediated cytotoxicity.J Immunol. 171: 368-79.5. Grotzke, J.E.et al.(2009) The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle.PLoS Pathog. 5: e1000374.6. Koch, N.et al.(2009) IL-10 protects monocytes and macrophages from complement-mediated lysis.J Leukoc Biol. 86: 155-66.7. Smith, A.C.et al.(2005) Interaction of the Salmonella-containing vacuole with the endocytic recycling system.J Biol Chem. 280: 24634-41.8. Watling, D.et al.(2008) Multiple kinases in the interferon-gamma response.Proc Natl Acad Sci U S A. 105: 6051-6.9. Lask, A.et al.(2011) TCR-Independent Killing of B Cell Malignancies by Anti-Third-Party CTLs: The Critical Role of MHC-CD8 Engagement.J Immunol. 187: 2006-14.10. Barnstable, C.J.et al.(1978) Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis.Cell. 14 (1): 9-20.

技术参数

产品应用 Flow

产品类型 Monoclonal Antibody

推荐用于 Flow

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