mouse anti human SQSTM1:Preservative Free
货号：MCA4265Z
规格：0.1 mg
价格：6180
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原：SQSTM1
物种：人
宿主：小鼠
抗体亚型：IgG2a
克隆号：2C11
荧光染料：Preservative Free
| 产品介绍 | | |
| Mouse anti Human SQSTM1 antibody, clone 2C11recognizes human SQSTM1, also known as Sequestosome-1, p62 or EBIAP. SQSTM1 is a ~62kDa ubiquitously expressed molecule bearing an N-terminalOPRdomain which mediates homo-oligomerization and interactions with other proteins. SQSTM1 also bears a C-terminalUBAdomain, responsible for binding to poly-ubiquitinated substrates.SQSTM1 is involved in the autophagic degradation of poly-ubiquitinated proteins (Weiet al.2013) and in bone remodelling through activation of of osteoclasts. Mutations in the SQSTM1 gene have been implicated in Paget's disease of bone (Laurinet al.2002)Mouse anti human SQSTM1, clone 2C11 has been used successfully for the identification of SQSTM1 in Hela cells by western blotting. |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein A from ascites |
| Buffer Solution | Phosphate buffered saline |
| Preservative Stabilisers | None present |
| Immunogen | Recombinant protein corresponding to aa 1 - 441 of human SQSTM1. |
| Approx. Protein Concentrations | Ig concentration 0.5 mg/ml |
| Fusion Partners | Spleen cells from BALB/c mice were fused with cells from the Sp2/0 myeloma cell line. |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Store at -20℃ only.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Western Blotting | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
技术参数 产品应用 IF;WB
产品类型 Monoclonal Antibody
推荐用于 IF;WB
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