Mouse anti human Cytochrome C antibody, clone 2G8
货号：MCA2740
规格：0.1 mg
价格：2652
产品类型：流式抗体
品牌：Bio-Rad
抗原：Cytochrome C
物种：人
宿主：小鼠
抗体亚型：IgG1
克隆号：2G8
荧光染料：Purified
| 产品介绍 | | |
| Mouse anti human Cytochrome C antibody, clone 2G8recognises cytochrome c, originally termed Apaf-2, an evolutionarily conserved protein which acts as an essential mitochondrial electron carrier between respirable substrates and oxygen, during aerobic energy production.A second major function for cytochrome c is its role as an intermediate in apoptosis, both through its association with inositol-3-phosphate receptor (IP3 receptor) which acts as an ER calcium release channel, and its association with apoptotic protease activating factor 1 (Apaf-1), resulting in the formation of the apoptosome protein complex which then recruits and activates pro-caspase 9 (Apaf-3).Mouse anti human Cytochrome C antibody, clone 2G8 is reported to block the role of cytochrome c as a co-factor in the activation of caspase 9 (Neameet al.1998) . Removal of sodium azide is recommended prior to use in functional assays. |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein A |
| Buffer Solution | Phosphate buffered saline |
| Immunogen | Human cytochrome c. |
| Fusion Partners | Spleen cells from immunised BALB/c mice were fused with cells of the NS0/1 mouse myeloma cell line. |
| Preservative Stabilisers | <0.1% Sodium Azide (NaN3) |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Flow Cytometry | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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| 文献 |
| 1.Neame, S.J.et al.(1998) Blocking cytochrome c activity within intact neurons inhibits apoptosis.J Cell Biol. 142 (6): 1583-93. |
技术参数 产品应用 Flow；Elisa
产品类型 Monoclonal Antibody
推荐用于 Flow；Elisa
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