mouse anti human C3d
货号：MCA2606
规格：0.1 ml
价格：6604
产品类型：流式抗体
品牌：Bio-Rad
抗原：C3d
物种：人
宿主：小鼠
抗体亚型：IgG1
克隆号：053A-1149.3.1.4 (also known as 1003)
荧光染料：Purified
| 产品介绍 | | |
| Mouse anti Human C3d antibody, clone 053A-1149.3.1.4recognizes human complement component 3d (C3d), a ~33 kDa polypeptide fragment generated over the course of complement activation where complement 3 (C3) convertases cleave C3 to C3b, which is further degraded into iC3b and C3dg/C3d.C3d is involved in the regulation of many aspects of the immune response, including antigen processing and presentation. The C3d/antigen complex mediates B cell activation by simultaneously binding antigen-specific surface bound immunoglobulin and CD21, lowering the complement activation threshold. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation. |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified Ig - liquid |
| Preparation | Purified Ig prepared by affinity chromatography on Protein A from ascites |
| Buffer Solution | Borate buffered saline |
| Immunogen | Purified C3d from human plasma. |
| Approx. Protein Concentrations | Current, batch-specific concentration 1.13 mg/ml |
| Preservative Stabilisers | 0.1% Sodium Azide (NaN3) |
| Regulatory | For research purposes only |
| Guarantee | Guaranteed until date of expiry. Please see product label. |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Flow Cytometry | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
| 推荐产品 |
| Description | Product Code | Applications | Pack Size |
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests/1ml |
| 文献 |
- Barilla-LaBarca, M.L.et al.(2002) Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells.J Immunol. 168 (12): 6298-304.
- Gay, F. (2013) Staphylococcal immune complexes and myelinolytic toxin in early acute multiple sclerosis lesions-An immunohistological study supported by multifactorial cluster analysis and antigen-imprint isoelectric focusing.Mult Scler Relat Disord. 2 (3): 213-32.
- Fujieda, M.et al.(2012) L-ficolin and capsular polysaccharide-specific IgG in cord serum contribute synergistically to opsonophagocytic killing of serotype III and V group B streptococci.Infect Immun. 80 (6): 2053-60.
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技术参数 产品应用 Flow;IHC(F);WB;ELISA
产品类型 单克隆抗体
推荐用于 Flow;IHC(F);WB;ELISA
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