Mouse anti Human MMP-9 Activated antibody, clone 4A3
货号：MCA2736GA,MCA2736
规格：0.1 mg,0.2 mg
价格：3868,6630
产品类型：免疫组化一抗
品牌：Bio-Rad
物种：人
宿主：小鼠
抗体亚型：IgG1
克隆号：4A3
荧光染料：Purified
| 产品介绍 | | |
| Mouse anti Human MMP-9 Activated antibody, clone 4A3recognizes the active form of human matrix metalloproteinase 9 (MMP-9). The MMP’s are zinc-dependent endopeptidases responsible for degrading the extracellular matrix. They are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMP’s are synthesised as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-9 is a gelatinase, cleaving type IV collagen and gelatin. The gelatinases have an additional gelatin-binding domain inserted in the catalytic domain. MMP-9, alongside other MMPs, plays a role in normal tissue remodeling such as embryonic development, ovulation, mammary gland involution and wound healing. It is important in the early stages of tumor invasion as it degrades the type IV collagen in the basement membrane.Mouse anti Human MMP-9 Activated antibody, clone 4A3 recognizes only the active form of MMP-9. It does not react with the MMP-9 proenzyme or the active or proenzyme forms of MMP-2. |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein A |
| Buffer Solution | Phosphate buffered saline |
| Immunogen | Ovalbumin conjugated synthetic peptide corresponding to a region within the N-terminus of human MMP-9. |
| Fusion Partners | Spleen cells from immunised Balb/c mice were fused with cells of the Ag8563 myeloma cell line. |
| Preservative Stabilisers | Pack Size: 0.2 mg0.09% Sodium Azide (NaN3)Pack Size: 0.1 mg<0.1% Sodium Azide (NaN3) |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Flow Cytometry | √ | 1/50 | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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| 文献 |
| 1.Duncan, M.E.et al.(1998) Human matrix metalloproteinase-9: activation by limited trypsin treatment and generation of monoclonal antibodies specific for the activated form.Eur J Biochem. 258 (1): 37-43.2.Šelemetjev Set al.(2016) Coexpressed High Levels of VEGF-C and Active MMP-9 Are Associated With Lymphatic Spreading and Local Invasiveness of Papillary Thyroid Carcinoma.Am J Clin Pathol. Nov 2. pii: aqw184. [Epub ahead of print]3.Dede, E.et al.(2021) The effects of exercise training on cardiac matrix metalloproteinases activity and cardiac function in mice with diabetic cardiomyopathyBiochem Biophys Res Comm. 09 Nov [Epub ahead of print]. |
技术参数 产品应用 WB
产品类型 Monoclonal Antibody
推荐用于 WB
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