Mouse anti Human CDw328 antibody, clone 5-386
货号：MCA2522PE
规格：100 Tests
价格：3893
产品类型：流式抗体
品牌：Bio-Rad
抗原：CDw328
物种：人
宿主：小鼠
抗体亚型：IgG1
克隆号：5-386
荧光染料：PE
| 产品介绍 | | |
| Mouse anti Human CDw328 antibody, clone 5-386recognizes human CDw328, a type I transmembrane glycoprotein and member of the Siglec (sialic acid binding Ig-like lectin) family, designated Siglec-7, originally identified as an inhibitory NK cell receptor (NKR) and negative regulator of NK activation, attributed to ITIM recruitment of SHP-1 phosphatase.CDw328 is expressed predominantly by natural killer cells (NK) and to a lesser extent by monocytes and granulocytes and, like Siglec-5 (CD170), has been shown to bind to sialylated ligands of targets through recognition of sialic acid in both the alpha-2,3- and alpha-2,6- glycosidic linkage. |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG conjugated to R. Phycoerythrin (RPE) - liquid |
| Reconstitution | Reconstitute with 1.0ml distilled water |
| Preparation | Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
| Buffer Solution | Phosphate buffered saline |
| Preservative Stabilisers | 0.09% Sodium Azide (NaN3)1% Bovine Serum Albumin5% Sucrose |
| Fusion Partners | Spleen cells from immunised Balb/c mice were fused with cells of the X63-Ag8.653 myeloma cell line. |
| Max Ex/Em | Fluorophore | Excitation Max (nm) | Emission Max (nm) |
| RPE 488nm laser | 496 | 578 |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Prior to reconstitution store at +4℃.After reconstitution store at +4℃.DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Flow Cytometry | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
| 推荐产品 |
| Description | Product Code | Applications | Pack Size |
| Rat IgG2a Negative Control:RPE | MCA1212PE | F | 100 Tests |
| 文献 |
| 1.Izquierdo-useros, N.et al.(2012) Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides.PLoS Biol. 10 (12): e1001448.2.Perez-Zsolt, D.et al.(2019) Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry.Nat Microbiol. 4 (9): 1558-70 |
技术参数 产品应用 Flow
产品类型 Monoclonal Antibody
推荐用于 Flow
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