Rat anti mouse TREM-1:Low Endotoxin
货号：MCA2578EL
规格：0.5 mg
价格：5041
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原：TREM-1
物种：小鼠
宿主：大鼠
抗体亚型：IgG2a
克隆号：L5-B8.2A12.3A12
荧光染料：Low Endotoxin
| 产品介绍 | | |
| Rat anti Mouse Trem-1 antibody, clone L5-B8.2A12.3A12recognizes mouse triggering receptor expressed on myeloid cells 1 (TREM-1), a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes. TREM-1 is involved in the microbial inflammatory response. It acts in conjunction with the adaptor protein DAP12 to activate neutrophils and monocytes, leading to the secretion of pro-inflammatory mediators and enhancement of the inflammatory response. Microbial infection also induces the release of soluble form of TREM-1 from monocytes, which is reported to act as an inhibitor of TREM-1.TREM-1 mediates the septic shock pathway, and blocking TREM-1 has been reported to reduce inflammation and increase survival in certain models of bacterial infection. |
| 产品详情 | | |
| Target Species | Mouse |
| Product Form | Purified IgG - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
| Buffer Solution | Phosphate buffered saline |
| Immunogen | Mouse TREM-1 Fc fusion protein. |
| Approx. Protein Concentrations | IgG concentration 1.0mg/ml |
| Preservative Stabilisers | None present |
| Endotoxin Level | < 0.01 EU/ug |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Store at -20℃ only.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Flow Cytometry | √ | 1/25 | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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| Description | Product Code | Applications | Pack Size |
| Goat anti Rat IgG:Alk. Phos. (Mouse Adsorbed) | STAR131A | C;WB | 1ml |
| 文献 |
| 1.Wang, F.et al.(2012) Blocking TREM-1 signaling prolongs survival of mice withPseudomonas aeruginosainduced sepsis.Cell Immunol. 272 (2): 251-8. |
技术参数 产品应用 Flow
产品类型 单克隆抗体
推荐用于 Flow
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