Rat anti Human EGF Receptor:RPE
货号：MCA1784PE
规格：100 Tests
价格：3893
产品类型：流式抗体
品牌：Bio-Rad
抗原：EGF Receptor
物种：人
宿主：大鼠
抗体亚型：IgG1
克隆号：ICR10
荧光染料：PE
| 产品介绍 | | |
| Rat anti Human EGF Receptor antibody, clone ICR10recognizes the human epidermal growth factor receptor (EGF-R), which is over expressed in a high proportion of breast cancer cells and in a range of other carcinomas.High level expression of EGFR is often associated with advanced disease and poor prognosis.Rat anti Human EGF Receptor antibody, clone ICR10 binds to epitope B from EGFR (Lottazet al.2010andModjtahediet al.1993) and has an affinity of 6.7 x 10-9M. |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized |
| Preparation | Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
| Reconstitution | Reconstitute with 1.0 ml distilled water |
| Buffer Solution | Phosphate buffered saline |
| Preservative Stabilisers | 0.09% Sodium Azide (NaN3)1% Bovine Serum Albumin |
| Approx. Protein Concentrations | IgG concentration 0.1mg/ml |
| Immunogen | Extracellular domain of human EGF-receptor from head and neck carcinoma. |
| Max Ex/Em | Fluorophore | Excitation Max (nm) | Emission Max (nm) |
| RPE 488nm laser | 496 | 578 |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Prior to reconstitution store at +4℃. Following reconstitution store at +4℃.DO NOT FREEZE.This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Flow Cytometry | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
| 推荐产品 |
| Description | Product Code | Applications | Pack Size |
| Rat IgG2a Negative Control:RPE | MCA6005PE | F | 0.1mg |
| 文献 |
| 1.Modjtahedi, H. & Dean, C. (1994) The receptor for EGF and its ligands - expression, prognostic value and target for therapy in cancer (review).Int J Oncol. 4 (2): 277-96.2.Lottaz,C.et al.(2010) Transcriptional Profiles of CD133+ and CD133- Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of OriginCancer Res. 70: 2030-40.3.Modjtahedi, H.et al.(1993) Antitumor activity of combinations of antibodies directed against different epitopes on the extracellular domain of the human EGF receptor.Cell Biophys. 22 (1-3): 129-46.4.Modjtahedi, H.et al.(2012) Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10.Br J Cancer. 106 (5): 883-8. |
技术参数 产品应用 Flow
产品类型 Monoclonal Antibody
推荐用于 Flow
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