Rat anti Mouse CD11a antibody, clone I21/7
货号：MCA1368GT,MCA1368G
规格：25 µg,0.25 mg
价格：825,3043
产品类型：流式抗体
品牌：Bio-Rad
抗原：CD11a
物种：小鼠
宿主：大鼠
抗体亚型：IgG2a
克隆号：I21/7
荧光染料：Purified
| 产品介绍 | | |
| Rat anti Mouse CD11a antibody, clone I21/7recognizes murine CD11a, a ~170-180 kDa type I membrane glycoprotein, also known as the integrin alpha L subunit. CD11a is a member of the integrin family of adhesion molecules. CD11a is expressed on all leucocytes and associates with CD18 to form a heterodimer at the cell surface. The CD11a/CD18 heterodimer binds to intercellular adhesion molecules (ICAM); ICAM1, ICAM-2 and ICAM-3 and is involved in cell-cell adhesion processes.Rat anti Mouse CD11a antibody, clone I21/7 is reported to block the cytolytic activity of cytotoxic T cell lines (Trowbridge and Omary 1981). |
| 产品详情 | | |
Target Species | Mouse |
| Product Form | Purified IgG - liquid |
Preparation | Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant. |
BufferSolution | Phosphate buffered saline |
Preservative Stabilisers | 0.09% Sodium Azide |
| Carrier Free | Yes |
| Immunogen | Whole BW5147 cells. |
| Approx. Protein Concentrations | IgG concentration 1.0mg/ml |
Regulatory | For research purposes only |
Guarantee | 12 monthsfrom date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
Flow Cytometry | √ | | |
| Immunoprecipitation | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications fromthe originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.Use 10ul of the suggested working dilution to label 1 x106cells in 100ul. |
| 同型对照 |
| Description | Product Code | Applications | Pack Size |
| Rat IgG2a Negative Control | MCA1212 | Flow;ELISA | 1mL |
| 文献 |
| 1. Talento, A.et al.(1993) A single administration of LFA-1 antibody confers prolonged allograft survival.Transplantation. 55 (2): 418-22.2. Campbell, S.B.et al.(2001) CD4 ligation promotes the IL-4-independent development of IL-4-producing clones from naive CD4(+) T cells.J Immunol. 167 (10): 5610-9.3. Kleinschnitz, C.et al.(2013) Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.Blood. 121: 679-6914. Falanga, P.B. & Butcher, E.C. (1991) Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model.Eur J Immunol. 21 (9): 2259-63.5.Chiu, W.C.et al.(2007) Effect of dietary fish oil supplementation on cellular adhesion molecule expression and tissue myeloperoxidase activity in diabetic mice with sepsis.Br J Nutr. 97 (4): 685-91.6. Xuemei, H.et al.(2020) Mesenchymal stem cell–derived exosomal microRNA-34c-5p ameliorates renal pericyte activation by inhibiting core fucosylationRes Sq 13 Oct [Epub ahead of print].7. Hu, X.et al.(2021) Bone marrow mesenchymal stem cell-derivedexosomal miR-34c-5p ameliorates RIF by inhibitingthe core fucosylation of multiple proteins.Mol Ther. S1525-0016(21)00519-0. |
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