Human anti Alemtuzumab antibody, clone AbD19189_hIgG1
货号：HCA199
规格：0.1 mg
价格：5100
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原：Alemtuzumab
物种：其它
宿主：人
抗体亚型：IgG1
克隆号：AbD19189_hIgG1
荧光染料：Purified
| 产品介绍 | | |
| Human anti Alemtuzumab antibody, clone AbD19189_hIgG1, recognizes alemtuzumab, a monoclonal antibody drug directed to human CD52 and used in the treatment of chronic lymphocytic leukemia (CLL), cutaneous T-cell lymphoma (CTCL) and T-cell lymphoma. Alemtuzumab is also used in some conditioning regimes for bone marrow transplantation, kidney transplantation and Islet cell transplantation along with clinical trial protocols for treatment of certain autoimmune diseases including multiple sclerosis.Human anti Alemtuzumab antibody, clone AbD19189_hIgG1 is an anti-idiotypic antibody that specifically recognizes the alemtuzumab humanized monoclonal antibody and can be used to measure the levels of alemtuzumab and biosimilar products using bioanalytical assays.This antibody, when conjugated to HRP, may be used in a bridging ELISA in conjunction with cloneAbD19189or cloneAbD16942.Clone AbD19189_hIgG1 has been demonstrated to inhibit the binding of alemtuzumab to CD52-positive human cells in flow cytometry. It also blocks the binding of Rat anti Human CD52 antibody,clone YTH34.5, the Rat monoclonal prototype antibody of alemtuzumab, to CD52+ cells. |
| 产品详情 | | |
| Product Form | Human IgG1 antibody selected from the HuCAL® phage display library and expressed in a human cell line. |
| Preparation | Purified IgG prepared by affinity chromatography on Protein A. |
| Buffer Solution | Phosphate buffered saline |
| Preservative Stabilisers | 0.01% Thiomersal |
| Immunogen | Alemtuzumab. |
| Affinity | The monovalent intrinsic affinity of this antibody was measured as KD=0.2 nM by real time, label-free molecular interaction analysis on immobilized alemtuzumab. |
| Approx. Protein ConcePurityntrations | Total protein concentration 0.5 mg/ml. |
| Acknowledgements | This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details. |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| ELISA | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
| 产品推荐 |
| Description | Product Code | Applications | Pack Size |
| Human anti Alemtuzumab | HCA174 | E | 0.1mg |
技术参数 产品应用 elisa
推荐用于 单克隆抗体
组成成分 elisa
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