| 产品介绍 | | |
| Rabbit anti DAI antibodyrecognizes human DAI, also known as Z-DNA Binding Protein (ZBP1), a ~46 kDa DNA binding protein belonging to a family of proteins that contain a Za domain which specifically binds to the left-handed Z-DNA and Z-RNA.DAI may be involved in processes such host response to neoplasia. cytosolic DAI can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of DAI to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK).DAI is highly expressed in lymphatic tissues such as lymph nodes, leukocytes, tonsil, bone marrow and spleen. Expression at a lower level is also seen in thymus, lung and liver. Multiple isoforms of DAI exist. |
| 产品详情 | | |
| Target Species | Human |
| Species Cross-Reactivity | Target Species | Cross Reactivity |
| Mouse | √ |
| Rat | √ |
| N.B. Antibody reactivity and working conditions may vary between species. |
| Product Form | Purified IgG - liquid |
| AntiserumPreparation | Antisera to human DAI were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography. |
| Preservative Stabilisers | Pack Size: 0.1 mg0.02% Sodium Azide (NaN3)Pack Size: 50 µg<0.1% Sodium Azide (NaN3) |
| Buffer Solution | Phosphate buffered saline |
| Immunogen | Synthetic peptide corresponding to an 18 amino acid sequence from near the carboxy terminus of human ZBP1. |
| Approx. Protein Concentrations | IgG concentration 1.0mg/ml |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Immunohistology - Paraffin1 | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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