Rabbit anti Human XEDAR antibody
货号：AHP1182
规格：0.1 mg
价格：2865
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原： XEDAR
物种：人
宿主：兔
抗体亚型：IgG
荧光染料：Purified
| 产品介绍 | | |
| Rabbit anti Human XEDAR antibodydetects human X-linked ectodermal dysplasia receptor (XEDAR), a ~33 kDa type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily. XEDAR is a homologue of the ectodermal dysplasia receptor (EDAR), and binds to an isoform of ectodysplasin termed EDA-A2. Binding of ectodysplasin to XEDAR results in the induction of apoptosis, and is thought to be involved ectodermal organ development. XEDAR may also be involved in skeletal muscle development.Two predominant isoforms of XEDAR exist; XEDAR-s and XEDAR-L, produced by alternative splicing. |
| 产品详情 | | |
Target Species | Human |
Product Form | Purified IgG - liquid |
Antiserum Preparation | Antisera to XEDAR were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. |
Buffer Solution | Phosphate buffered saline |
Preservative Stabilisers | 0.02%Sodium Azide |
Approx. Protein Concentrations | IgG concentration 1.0mg/ml |
Immunogen | Recombinant human XEDAR. |
Regulatory | For research purposes only |
Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
Application Name | Verified | Min Dilution | Max Dilution |
Western Blotting | √ | 0.5 | 2.0ug/ml |
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.- Western Blotting
- AHP1182 detects a band of approximately 33kDa in 293 cell lysates.
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| 文献 |
| 1. Sinha, S.K.et al.(2002) Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor.J Biol Chem. 277 (47): 44953-61.2. Sinha, S.K. & Chaudhary, P.M. (2004) Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism.J Biol Chem. 279 (40): 41873-81.3. Newton, K.et al.(2004) Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency.Mol Cell Biol. 24 (4): 1608-13. |
技术参数 产品应用 WB
产品类型 Polyclonal Antibody
推荐用于 WB
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