Goat anti Mouse CD289 antibody
货号：AAM74
规格：0.1 mg
价格：4420
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原：CD289
物种：小鼠
宿主：山羊
抗体亚型：IgG
荧光染料：Purified
| 产品介绍 | | |
| Goat anti Mouse CD289 antibodyrecognises murine Toll-like receptor 9, also known as CD289 or TLR9. CD289 is an 1032 amino acid ~120 kDa endosomal single pass type I transmembrane glycoprotein with a number ofleucine rich repeatsand a singleTIRdomain (UniProt: Q9NR96). Goat anti Mouse CD289 antibody recognizes an epitope within the N-terminal (NT) region of CD289, a member of the toll-like receptor family, which triggers MyD88 and TRAF6, resulting in NF-kappaB activation, cytokine secretion and the inflammatory response.CD289 acts as a receptor for unmethylated cytidine-phosphate-guanosine dinucleotides in bacterial DNA (CpG-DNA), playing a primary role in pathogen recognition and activation of innate immunity and has been shown to play a role in defence against systemic mouse cytomegalovirus infection.Goat anti Mouse CD289 antibody is reported as suitable for use in immunocytochemistry on acetone fixed cells. |
| 产品详情 | | |
Target Species | Mouse |
Product Form | Purified IgG - liquid |
Antiserum Preparation | Antiserum to mouse CD289 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography. |
Buffer Solution | Phosphate buffered saline |
Preservative Stabilisers | <0.1% Sodium Azide (NaN3)0.1% Bovine Serum Albumin |
Approx. Protein Concentrations | IgG concentration 1.0mg/ml |
Immunogen | Synthetic peptide LSLKYNNLTKVPRQLPPSLEY-C corresponding to amino acids 204-224 within the N-terminal region of mouse CD289. |
Regulatory | For research purposes only |
Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Store at -20℃only.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| 应用 | | |
Application Name | Verified | Min Dilution | Max Dilution |
Immunohistology - Paraffin | √ | 1:125 | |
Western Blotting | √ | 1:500 | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.Histology Positive Control TissueSpleen, thymus or tonsil |
| 二抗相关产品 |
Description | Product Code | Applications | Pack Size |
| Rabbit anti Goat IgG (Fc):FITC | STAR122F | Flow | 1 mg |
| Rabbit anti Goat IgG (Fc):HRP | STAR122P | C;E;WB | 1 mg |
| 数据 |
| Staining of paraffin embedded mouse thymus with Goat anti mouse CD289 (AAM74). |
| 文献 |
| 1. Ripoll, V.M.et al.(2010) Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses toStreptococcus pneumoniae.J Leukoc Biol. 87: 735-41. |
技术参数 产品应用 IHC(P);WB
产品类型 Polyclonal Antibody
推荐用于 IHC(P);WB
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