Mouse anti Human endothelin 1 antibody, clone IC4
货号：4113-1077
规格：0.1 mg
价格：2125
产品类型：免疫组化一抗
品牌：Bio-Rad
物种：人
宿主：小鼠
抗体亚型：IgG1
克隆号：IC4
荧光染料：Purified
| 产品介绍 | | |
| Mouse anti Human endothelin 1 antibody, clone IC4recognizes human endothelin 1 (ET-1). Endothelin-1 in it's precursor form is a 212 amino acid protein with a 17 aa signal peptide, an N-terminal pro-peptide region and a C-terminal pro-peptide region flanking the endothelin peptides, big endothelin-1 (38aa), the precursor of the smaller endothelin peptide which is cleaved by endothlin converting enzyme to produce the active endothelin-1 (21aa) peptide and a c-terminal fragment. Endothelin-1 is a potent vasoconstrictor with a molecular mass of approximately 25 kDa. Mouse anti human endothelin 1 antibody, clone IC4 shows less than 10% reactivity with endothelin 3.Plasma levels of both endothlin-1 and big endothlin-1 are useful as predictors for survival of patients with congestive heart failure (Rodehefferet al.1992). However, the half life of the endothlin1 peptide in human plasma is very short (c1.0 mins) and measurement of big-endothlin-1 may be a more reliable measure of the endothlin secretory pathway activity (Hemsénet al.1995). |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant |
| Buffer Solution | Phosphate buffered saline |
| Preservative Stabilisers | 0.1%Sodium Azide (NaN3) |
| Immunoge | C-terminal fragment of human endothelin 1. |
| Approx. Protein Concentrations | 1.0 mg/ml |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| IRMA | √ | 0.5 µg/ml | 1 µg/ml |
| Immunohistology - Frozen | √ | 10 µg/ml | 20 µg/ml |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
| 二抗 |
| Description | Product Code | Applications | Pack Size |
| Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed) | STAR117F | F | 0.5mg |
| Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed) | STAR117A | E,WB | 0.5mg |
| 文献 |
| 1.Papalambros, E.et al.(2003) Immunohistochemical expression of metalloproteinases MMP-2 and MMP-9 in abdominal aortic aneurysms: correlation with symptoms and aortic diameter.Int J Mol Med. 12 (6): 965-8. |
技术参数 产品应用 IHC
产品类型 Monoclonal Antibody
推荐用于 IHC
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