Recombinant Human sCD8α
货号：310-41-10,310-41-100,310-41-1000,310-41-250,310-41-50,310-41-500
规格：10ug,100ug,1mg,250ug,50ug,500ug
价格：585,3202,12850,5608,1425,8332
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8α chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8α. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naïve CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-β1. PeproTech’s CHO cell-derived Recombinant Human sCD8α is a monomeric glycoprotein of 161 amino acid residues, which corresponds to the extracellular domain of CD8α. Peprotech’s CHO cell-derived Recombinant Human sCD8α has a calculated molecular weight of 17.6 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of approximately 27-29 kDa by SDS-PAGE analysis, under reducing conditions.来源:CHO cells别名:CD8A, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2氨基酸序列:SQFRVSPLDR TWNLGETVEL KCQVLLSNPT SGCSWLFQPR GAAASPTFLL YLSQNKPKAA EGLDTQRFSG KRLGDTFVLT LSDFRRENEG YYFCSALSNS IMYFSHFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC D纯度:≥ 95% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to induce plate adhesion of PHA-stimulated Jurkat cells.Calculated Molecular Weight:17.6 kDaAccession Number:P01732Gene ID:925原产国:USA |
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