其它信息：

Application

FA

Synonyms:

DZNep, NSC 617989

Formulation:

Crystalline solid

Chemical Name:

(1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol

Molecular Formula:

C12H14N4O3

Molecular Weight:

262.3

CAS Number

102052-95-9

Purity:

≥97%

Storage Conditions:

Product should be kept at -20°C.

References:

Fiskus, W., Wang, Y., Sreekumar, A., Buckley, K. M., Shi, H., Jillella, A., ... & Bhalla, K. N. (2009). Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells.Blood,114(13), 2733-2743.

Glazer, R. I., Hartman, K. D., Knode, M. C., Richard, M. M., Chiang, P. K., Tseng, C. K., & Marquez, V. E. (1986). 3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60.Biochemical and biophysical research communications,135(2), 688-694.

Bray, M., Raymond, J. L., Geisbert, T., & Baker, R. O. (2002). 3-Deazaneplanocin A induces massively increased interferon-α production in Ebola virus-infected mice.Antiviral research,55(1), 151-159.