Applications

FA

Synonyms:

Alitretinoin, 9-cis-Tretinoin, Panretin

Formulation:

Crystalline solid

Chemical Name:

(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid

Molecular Formula:

C₉H₁₄N₄O₅

Molecular Weight:

258.2

CAS Number

5300-03-8

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M., & Thaller, C. (1992). 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.Cell,68(2), 397-406.

Levin, A. A., Sturzenbecker, L. J., Kazmer, S., Bosakowski, T., Huselton, C., Allenby, G., ... & Grippo, J. F. (1992). 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα.

MacDonald, P. N., Dowd, D. R., Nakajima, S., Galligan, M. A., Reeder, M. C., Haussler, C. A., ... & Haussler, M. R. (1993). Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1, 25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene.Molecular and cellular biology,13(9), 5907-5917.