Applications

FA

Synonyms:

Acadesine, AICA ribonucleoside, aminoimidazole carboxamide ribonucleoside, ARA100,1-ribosyl-4-carboxamido-5-aminoimidazole

Formulation:

Crystalline solid

Chemical Name:

5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide

Molecular Formula:

C₉H₁₄N₄O₅

Molecular Weight:

258.2

CAS Number

2627-69-2

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Sullivan, J. E., Brocklehurst, K. J., Marley, A. E., Carey, F., Carling, D., & Beri, R. K. (1994). Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase.FEBS letters,353(1), 33-36.

Young, M. E., Radda, G. K., & Leighton, B. (1996). Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR—an activator of AMP-activated protein kinase.FEBS letters,382(1), 43-47.

Iglesias, M. A., Ye, J. M., Frangioudakis, G., Saha, A. K., Tomas, E., Ruderman, N. B., ... & Kraegen, E. W. (2002). AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats.Diabetes,51(10), 2886-2894.