Applications

FA

Synonyms:

11-Deoxojervine, MLS006010945, Jervine

Formulation:

Crystalline solid

Chemical Name:

(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol

Molecular Formula:

C₂₇H₄₁NO₂

Molecular Weight:

411.6

CAS Number

4449-51-8

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Taipale, J., Chen, J. K., Cooper, M. K., Wang, B., Mann, R. K., Milenkovic, L., ... & Beachy, P. A. (2000). Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.Nature,406(6799), 1005-1009.

Chen, J. K., Taipale, J., Cooper, M. K., & Beachy, P. A. (2002). Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.Genes & development,16(21), 2743-2748.

Bar, E. E., Chaudhry, A., Lin, A., Fan, X., Schreck, K., Matsui, W., ... & Eberhart, C. G. (2007). Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma.Stem cells,25(10), 2524-2533.