Applications

FA

Synonyms:

Cyclic Pifithrin-alpha, 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr, Pifithrin-beta hydrobromide

Formulation:

Crystalline solid

Chemical Name:

2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole;hydrobromide

Molecular Formula:

C₁₆H₁₆N₂S HBr

Molecular Weight:

349.3

CAS Number

511296-88-1

Purity:

≥95%

Storage Conditions:

Product should be kept at -20°C.

References:

Liao, J., Marumoto, T., Yamaguchi, S., Okano, S., Takeda, N., Sakamoto, C., ... & Tani, K. (2013). Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells.Molecular Therapy,21(6), 1242-1250.

Zuco, V., & Zunino, F. (2008). Cyclic pifithrin-α sensitizes wild type p53 tumor cells to antimicrotubule agent–induced apoptosis.Neoplasia,10(6), 587-596.

Pietrancosta, N., Maina, F., Dono, R., Moumen, A., Garino, C., Laras, Y., ... & Kraus, J. L. (2005). Novel cyclized Pifithrin-α p53 inactivators: synthesis and biological studies.Bioorganic & medicinal chemistry letters,15(6), 1561-1564.