DMOG

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DMOG

货号:8946314-10,8946314-50

规格:10 mg,50mg

价格:220,770

产品类型:小分子化合物

品牌:Biogems

DMOG is a cell permeable Prolyl 4-hydroxylase (P4H) inhibitor which activates the hypoxia-inducible factor (HIF) in cultured cells. DMOG is reported to delay neuronal cell death caused by trophic factor deprivation through a HIF-1 alpha-independent, glucose-dependent mechanism.

Additional Information

Applications

FA

Synonyms:

Dimethyloxallyl glycine, dimethyloxalylglycine, methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate

Formulation:

Crystalline solid

Chemical Name:

methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetat

Molecular Formula:

C6H9NO5

Molecular Weight:

175.1

CAS Number

89464-63-1

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Hill, P., Shukla, D., Tran, M. G., Aragones, J., Cook, H. T., Carmeliet, P., & Maxwell, P. H. (2008). Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury.Journal of the American Society of Nephrology,19(1), 39-46.

Milkiewicz, M., Pugh, C. W., & Egginton, S. (2004). Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.The Journal of physiology,560(1), 21-26.

Sears, J. E., Hoppe, G., Ebrahem, Q., & Anand-Apte, B. (2008). Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy.Proceedings of the National Academy of Sciences,105(50), 19898-19903.

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