Applications

FA

Synonyms:

PD-0325901, ZINC03938683, NCGC00189075-01, (R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

Formulation:

Crystalline solid

Chemical Name:

N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide

Molecular Formula:

C₁₆H₁₄F₃IN₂O₄

Molecular Weight:

482.2

CAS Number

391210-10-9

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Sebolt-Leopold, J. S., Merriman, R., Omer, C., Tecle, H., Bridges, A., Klohs, W., ... & Leopold, W. R. (2004). The biological profile of PD 0325901: A second generation analog of CI-1040 with improved pharmaceutical potential.Cancer Research,64(7 Supplement), 925-925.

Haura, E. B., Ricart, A. D., Larson, T. G., Stella, P. J., Bazhenova, L., Miller, V. A., ... & Gadgeel, S. M. (2010). A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non–small cell lung cancer.Clinical Cancer Research,16(8), 2450-2457.

Leyton, J., Smith, G., Lees, M., Perumal, M., Aigbirhio, F. I., Golovko, O., ... & Aboagye, E. O. (2008). Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901.Molecular cancer therapeutics,7(9), 3112-3121.