Applications

FA

Synonyms:

PD173074, UNII-A4TLL8634Y, FGF/VEGF Receptor Tyrosine Kinase Inhibitor

Formulation:

Crystalline solid

Chemical Name:

1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

Molecular Formula:

C₂₈H₄₁N₇O₃

Molecular Weight:

523.7

CAS Number

219580-11-7

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Skaper, S. D., Kee, W. J., Facci, L., Macdonald, G., Doherty, P., & Walsh, F. S. (2000). The FGFR1 Inhibitor PD 173074 Selectively and Potently Antagonizes FGF‐2 Neurotrophic and Neurotropic Effects.Journal of neurochemistry,75(4), 1520-1527.

Mohammadi, M., Froum, S., Hamby, J. M., Schroeder, M. C., Panek, R. L., Lu, G. H., ... & Hubbard, S. R. (1998). Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.The EMBO journal,17(20), 5896-5904.

Dimitroff, C. J., Klohs, W., Sharma, A., Pera, P., Driscoll, D., Veith, J., ... & Bernacki, R. J. (1999). Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy.Investigational new drugs,17(2), 121-135.