Applications

FA

Synonyms:

Sirolimus, Rapamune, AY 22989

Formulation:

Crystalline solid

Chemical Name:

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)­9,10,12,13,14,21,22,23,24,25,26,27,32,33,34, 34a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2­[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy­6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4] oxaazacyclohentriacontine­1,5,11,28,29 (4H,6H,31H)-pentone

Molecular Formula:

C₅₁H₇₉NO₁₃

Molecular Weight:

914.2

CAS Number

53123-88-9

Purity:

≥95%

Storage Conditions:

Product should be kept at -20°C.

References:

Nourse, J., Firpo, E., Flanagan, W. M., Coats, S., Polyak, K., Lee, M. H., ... & Roberts, J. M. (1994). lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin.

Kuo, C. J., Chung, J., Fiorentino, D. F., Flanagan, W. M., Blenis, J., & Crabtree, G. R. (1992). Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase.Nature,358(6381), 70-73.

Hidalgo, M., & Rowinsky, E. K. (2000). The rapamycin-sensitive signal transduction pathway as a target for cancer therapy.Oncogene,19(56), 6680-6686.