Applications

FA

Synonyms:

Y 27632, N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide, trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride

Formulation:

Crystalline solid

Chemical Name:

4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide;dihydrochloride

Molecular Formula:

C₁₄H₂₁N₃O 2HCl

Molecular Weight:

320.3

CAS Number

129830-38-2

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Ishizaki, T., Uehata, M., Tamechika, I., Keel, J., Nonomura, K., Maekawa, M., & Narumiya, S. (2000). Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.Molecular pharmacology,57(5), 976-983.

Fu, X., Gong, M. C., Jia, T., Somlyo, A. V., & Somlyo, A. P. (1998). The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPγS-, and phorbol ester-induced Ca 2+-sensitization of smooth muscle.FEBS letters,440(1), 183-187.

Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., ... & Sasai, Y. (2007). A ROCK inhibitor permits survival of dissociated human embryonic stem cells.Nature biotechnology,25(6), 681-686.