Applications

FA

Synonyms:

IN1416, CHEMBL286977, pyrimidin-2-one ribonucleoside, NSC 309132

Formulation:

Crystalline solid

Chemical Name:

1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

Molecular Formula:

C₉H₁₂N₂O₅

Molecular Weight:

228.2

CAS Number

3690-10-6

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Cheng, J. C., Matsen, C. B., Gonzales, F. A., Ye, W., Greer, S., Marquez, V. E., ... & Selker, E. U. (2003). Inhibition of DNA methylation and reactivation of silenced genes by zebularine.Journal of the National Cancer Institute,95(5), 399-409.

Zhou, L., Cheng, X., Connolly, B. A., Dickman, M. J., Hurd, P. J., & Hornby, D. P. (2002). Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases.Journal of molecular biology,321(4), 591-599.

Addison, M. K., Coley, L. W., Gentry, G. T., Godke, R. A., & Bondioli, K. R. (2011). 209 epigenetic modification with zebularine and valproic acid and expression of pluripotency genes in bovine adipose stem cells.Reproduction, Fertility and Development,24(1), 216-217.

Naeem, N., Haneef, K., Kabir, N., Iqbal, H., Jamall, S., & Salim, A. (2013). DNA Methylation Inhibitors, 5‐azacytidine and Zebularine Potentiate the Transdifferentiation of Rat Bone Marrow Mesenchymal Stem Cells into Cardiomyocytes.Cardiovascular therapeutics,31(4), 201-209.