Recombinant Murine GDF-5 (BMP-14/CDMP-1)
货号：315-24-10,315-24-100,315-24-1000,315-24-250,315-24-50,315-24-500
规格：10ug,100ug,1mg,250ug,50ug,500ug
价格：643,3522,14134,6168,1568,9165
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述:GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicatedin Hunter-Thompson type dwarfism andin Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino acid polypeptide chains (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 348 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant Murine GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.别名:Growth/Differentiation Factor-5, BMP-14, Cartilage-Derived Morphogenetic Protein-1 (CDMP-1)氨基酸序列:APLANRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR来源:E.coli纯度:Greater than 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expectedED50for this effect is 1.0-2.0 µg/ml.Calculated Molecular Weight:27 kDaAccession Number:P43027Gene ID:14563交叉反应:Mouse原产地:USA仅用于科研，不能用于临床和诊断。 |
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