Animal-Free Recombinant Human IL-21
货号：AF-200-21-2,AF-200-21-10,AF-200-21-50,AF-200-21-100,AF-200-21-250,AF-200-21-500,AF-200-21-1000
规格：2ug,10ug,50ug,100ug,250ug,500ug,1mg
价格：1250,2830,13160,21940,3840,57050,87780
产品类型：细胞因子添加物
品牌：PeproTech
| 产品详情产品编号：AF-200-21产品描述：IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T cell-stimulated B cells into plasma cells and memory B cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in naïve B cells and stimulated B cells in the absence of T cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Human IL-21 is a 15.4 kDa protein consisting of 132 amino acid residues.Manufactured using all Animal-Free reagents.Source:E.coliSynonyms:Interleukin-21, Za11AA Sequence:MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DSPurity:≥ 98% by SDS-PAGE gel and HPLC analyses.Biological Activity:Determined by its ability to stimulate the proliferation of human ANBL-6 cells. The expectedED50is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x106units/mg.Calculated Molecular Weight:15.4 kDaAccession Number:Q9HBE4Gene ID:59067crossreactivity:Human,MouseCountry Of Origin:USANot for human use. |
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