Recombinant Human ANG-1
货号： 130-06-5,130-06-20,130-06-100,130-06-500,130-06-1000
规格：5μg,20μg,100μg,500μg,1000μg
价格：640,1560,9936,31632,48759
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：Angiopoietin-1 (ANG-1) is a secreted ligand for Tie-2, a tyrosine-kinase receptor expressed primarily on vascular endothelial cells and early hematopoietic cells. ANG-1/Tie-2 signaling promotes angiogenesis during the development, remodeling, and repair of the vascular system. Transgenic mice lacking expression of either ANG-1 or Tie-2 fail to develop a fully functional cardiovascular system and die before birth. Postnatally, the angiogenic activity of ANG-1/Tie-2 is required during normal tissue repair and remodeling of the female endometrium in the menstrual cycle. ANG-1/Tie-2 signaling appears to be regulated by Angiopoietin-2 (ANG-2), a natural antagonist for Tie-2 that exerts its effects through an internal autocrine loop mechanism. In addition to suppressing endothelial cell activation by inhibiting the expression of adhesion and inflammatory molecules, ANG-1 enhances endothelial cell survival and capillary morphogenesis, and lessens capillary permeability. As such, ANG-1 has potential to become an effective therapeutic agent for treating various endothelium disorders, including several severe human pulmonary diseases. The efficacy of cell-based Ang-1 gene therapy for acute lung injury (ALI) has recently been studied in a rat model of ALI. The results of this study show that such therapy can markedly improve lung condition and suggest that ANG-1 therapy may represent a potential new strategy for the treatment and/or prevention of acute respiratory distress injury (ARDI), a significant cause of morbidity and mortality in critically ill patients. Recombinant Human ANG-1, derived from HeLa cells, is a C-terminal histidine tagged glycoprotein which migrates with an apparent molecular mass of 60.0 – 70.0 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows N-terminal sequences starting with Ser-20 and with Asp-70 of the 498 amino acid precursor protein. The calculated molecular weight of Recombinant Human ANG-1 is 56.3 kDa.来源:HeLa cells别名:Angiopoietin-1, ANGPT1, KIAA0003氨基酸序列:SNQRRSPENS GRRYNRIQHG QCAYTFILPE HDGNCRESTT DQYNTNALQR DAPHVEPDFS SQKLQHLEHV MENYTQWLQK LENYIVENMK SEMAQIQQNA VQNHTATMLE IGTSLLSQTA EQTRKLTDVE TQVLNQTSRL EIQLLENSLS TYKLEKQLLQ QTNEILKIHE KNSLLEHKIL EMEGKHKEEL DTLKEEKENL QGLVTRQTYI IQELEKQLNR ATTNNSVLQK QQLELMDTVH NLVNLCTKEG VLLKGGKREE EKPFRDCADV YQAGFNKSGI YTIYINNMPE PKKVFCNMDV NGGGWTVIQH REDGSLDFQR GWKEYKMGFG NPSGEYWLGN EFIFAITSQR QYMLRIELMD WEGNRAYSQY DRFHIGNEKQ NYRLYLKGHT GTAGKQSSLI LHGADFSTKD ADNDNCMCKC ALMLTGGWWF DACGPSNLNG MFYTAGQNHG KLNGIKWHYF KGPSYSLRST TMMIRPLDFH HHHHH纯度:≥ 95% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to induce adhesion of human umbilical vein endothelial cells (HUVEC).Calculated Molecular Weight:56.3 kDaAccession Number:Q15389Gene ID:284注意:100μg is the largest vial size for this product.Larger sizes supplied as multiple 100μg vials.交叉反应:Human原产地:USA仅用于科研，不能用于临床和诊断。 |
product.subtitle.recentcitations |
第一作者 | Jeon, J S |
标题 | Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation. |
文献引用 | Proceedings of the National Academy of Sciences of the United States of America; 112(1) pg214-9 |
PubMed Id | 25524628 |
第一作者 | Hatfield, K |
标题 | Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators. |
文献引用 | British Journal of Haematology; 144(1) pg53-68 |
PubMed Id | 19016730 |
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