Recombinant Murine PDGF-BB
货号：315-18-10,315-18-100,315-18-1000,315-18-2,315-18-250,315-18-50,315-18-500
规格：10ug,100ug,1mg,2ug,250ug,50ug,500ug
价格：1568,9171,36743,643,16052,5501,23843
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述:PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of twoβ chains (218 total amino acids).别名:Platelet-Derived Growth Factor-BB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF)氨基酸序列:SLGSLAAAEP AVIAECKTRT EVFQISRNLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RASQVQMRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TIVTPRPVT来源:E.coli纯度:Greater than 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expectedED50for this effect is 1.0-2.0 ng/ml.Calculated Molecular Weight:24.4 kDaAccession Number:P31240Gene ID:18591交叉反应:Human,Monkey,Mouse,Rat原产地:USA仅用于科研，不能用于临床和诊断。 |
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