Recombinant Human CTGF

货号：120-19-100,120-19-1000,120-19-20,120-19-250,120-19-5,120-19-500

规格：100ug,1mg,20ug,250ug,5ug,500ug

价格：9126,36565,1560,15974,640,23727

产品类型：细胞因子添加物

品牌：PeproTech

产品描述：CTGF is a member of the CCN family of secreted cysteine-rich regulatory proteins, and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells. CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial and epithelial cells, and binds to IGF, TGF-β1 and BMP-4. Cell migration and adhesion are signaled through binding to specific cell surface integrins and to heparin sulfate proteoglycans. CTGF (98 a.a.), a lower molecular weight isoform containing the C-terminal portion of the full length CTGF protein, exerts full heparin binding, cell adhesion, and mitogenic CTGF activity. Mature Human CTGF is a 38.0 kDa secreted protein containing 323 amino acid residues. CTGF is comprised of four distinct structural domains (modules), which are identified as IGF-Binding Protein (IGF-BP), von Willebrand Factor C (VWFC), Thrombospondin type I (TSP type I), and C-terminal cysteine knot-like (CTCK) domains. Full length CTGF can be proteolytically cleaved in certain tissues to yield N-terminal truncated isoforms, which, depending on the isoform, contain only the TSP type I and CTCK domains or contain only the CTCK domain. Recombinant Human CTGF is an 11.0 kDa protein consisting of 97 amino acid residues.来源:E.coli别名:Connective TissueGrowth Factor, CCN2, Hypertrophic chondrocyte-specific protein 24 (HCS24)氨基酸序列:GKKCIRTPKI SKPIKFELSG CTSMKTYRAK FCGVCTDGRC CTPHRTTTLP VEFKCPDGEV MKKNMMFIKT CACHYNCPGD NDIFESLYYR KMYGDMA纯度:≥ 95% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by the dose-dependent stimulation of the proliferation of HUVEC cells. The expectedED50for this effect is 1.0-2.0 µg/ml.Calculated Molecular Weight:11 kDaAccession Number:P29279Gene ID:1490交叉反应:Chicken,Human,Mouse,Rat

product.subtitle.recentcitations
第一作者	Wu, Z
标题	CTGF facilitates cell-cell communication in chondrocytes via PI3K/Akt signalling pathway.
文献引用	Cell Proliferation; 54(3) pge13001
PubMed Id	33522639
第一作者	Wang, Y
标题	Exosomes from tendon stem cells promote injury tendon healing through balancing synthesis and degradation of the tendon extracellular matrix.
文献引用	Journal of Cellular and Molecular Medicine; 23(8) pg5475-5485
PubMed Id	31148334
第一作者	Li, Y
标题	PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.
文献引用	The Journal of Clinical Investigation; 129(3) pg1129-1151
PubMed Id	30741721

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