Recombinant Human GDF-5 (BMP-14/CDMP-1)
货号：120-01-10,120-01-100,120-01-1000,120-01-250,120-01-50,120-01-500
规格：10ug,100ug,1mg,250ug,50ug,500ug
价格：640,3505,14066,6139,1560,9121
产品类型：细胞因子添加物
品牌：PeproTech
| 产品详情产品编号：120-01产品描述：GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicatedin Hunter-Thompson type dwarfism andin Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant Human GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.Source:E.coliSynonyms:Growth/Differentiation Factor-5, BMP-14, Cartilage-Derived Morphogenetic Protein-1 (CDMP-1)AA Sequence (monomer):APLATRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCRPurity:≥ 98% by SDS-PAGE gel and HPLC analyses.Biological Activity:TheED50was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1.0-2.0 µg/ml.Calculated Molecular Weight:27 kDaAccession Number:P43026Gene ID:8200crossreactivity:Human,MouseCountry Of Origin:USANot for human use. |
| product.subtitle.recentcitations |
| 第一作者 | Takei, Y |
| 标题 | Quality assessment tests for tumorigenicity of human iPS cell-derived cartilage. |
| 文献引用 | Scientific Reports; 10(1) pg12794PubMed Id |
| PubMed Id | 32732907 |
| 第一作者 | Griffiths, R |
| 标题 | The Transcription Factor-microRNA Regulatory Network during hESC-chondrogenesis |
| 文献引用 | Scientific Reports; 10(1) pg4744PubMed Id |
| PubMed Id | 32179818 |
| 第一作者 | Hall, G N |
| 标题 | Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing |
| 文献引用 | Advanced science (Weinheim, Baden-Wurttemberg, Germany); 7 (2), 1902295PubMed Id |
| PubMed Id | 31993293 |
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