Recombinant Human HVEM-Fc
货号:310-27-100,310-27-1000,310-27-20,310-27-200,310-27-500
规格:100ug,1mg,20ug,200ug,500ug
价格:1425,9425,585,3526,6112
产品类型:细胞因子添加物
品牌:PeproTech
产品描述:HVEM belongs to the TNF Receptor superfamily of transmembrane proteins, and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues, including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade that results in the induction of transcription factors NF-κB and AP-1. LIGHT (TNFSF14) and TNF-β (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM, which tends to form disulfide-linked heterodimeric complexes in solution, can act as a “receptor decoy” resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-β. Recombinant Human HVEM-Fc Chimera is a 376 amino acid fusion protein that contains an N-terminal domain corresponding to the extracellular region of HVEM, and a C-terminal domain corresponding to residues 102 to 330 of human IgG1.The calculated molecular weight of Recombinant Human HVEM-Fc is 41.4 kDa.来源:Hi-5 Insect cells别名:HVEM, TNFSFR14, ATAR, TR2氨基酸序列:LPSCKEDEYP VGSECCPKCS PGYRVKEACG ELTGTVCEPC PPGTYIAHLN GLSKCLQCQM CDPAMGLRAS RNCSRTENAV CGCSPGHFCI VQDGDHCAAC RAYATSSPGQ RVQKGGTESQ DTLCQNCPPG TFSPNGTLEE CQHQTKRSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to neutralize 0.25 ng/ml of hTNFβ induced cytotoxicity on murine L929 cells. The expectedED50for this effect is 1.3-1.9 μg/ml of HVEM-Fc.Calculated Molecular Weight:41.4 kDaAccession Number:Q92956Gene ID:8764交叉反应:Mouse原产国:USA |
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